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KMID : 0370020000140000055
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Chung-Ang Journal of Pharmacal Sciences
2000 Volume.14 No. 0 p.55 ~ p.66
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Pharmacokinetic Study of Omeprazole-Cholestyramine Resin for Human
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Abstract
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We have performed the pharmacokinetic study of omeprazole- cholestyramine resinate, which has been developed to increase the stability of omeprazole, the well-known proton pump inhibitor, in an acidic condition. In the human experiments, AUC or T_max of oral administration of omeprazole-cholestyramine resinate is bioequivalent with omeprazole, but C_max was 20% higher in omeprazole-cholestyramine resinate than omeprazole. Omeprazole-cholestyramine resinate suppository showed higher C_max and shortened T_max, so it is expected to show a rapid absorption. These data suggest that omeprazole-cholestyramine resinate is more stable in acid and more rapidly absorbed than omeprazole.
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KEYWORD
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